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Rethinking Serotonin: What Gender Differences Truly Tell Us

I recently watched an engaging and highly insightful session by Dr. Vladimir Maletic, delivered at the 2023 NEI Congress under the title “Brain Networks, Circuits and Neurotransmitters: A Roadmap to Better Outcomes.” What stood out was the way complex neuroscience was made accessible while also dismantling several commonly held—but misleading—assumptions about mental health, particularly those related to gender and serotonin.

Serotonin is often casually labeled as the brain’s “happiness chemical.” However, as the session made clear, its role is far more sophisticated. Serotonin participates in extensive brain networks that influence emotional regulation, cognition, stress response, sleep, appetite, and resilience. Rather than acting alone, it works in coordination with hormones, receptors, neural circuits, and environmental factors.

Do Women Actually Have Less Serotonin?

One of the most persistent claims in popular discourse is that women have significantly lower serotonin levels than men. Dr. Maletic’s explanation helped unpack how this belief arose—and why it requires nuance.

Neuroimaging studies using PET scans suggest that, on average, serotonin synthesis in women may occur at a slower rate—roughly 30–50% lower—than in men. Crucially, this finding refers to the speed of production, not the total amount of serotonin present in the brain at any given time.

This distinction matters because it means women do not permanently have lower serotonin levels. It does not indicate a biological inadequacy, nor does it automatically translate into depression or anxiety. Serotonin activity is highly dynamic and influenced by hormonal changes, stress exposure, life experiences, receptor responsiveness, and overall brain network efficiency.

Why Hormonal Influence Is Central

A key theme of the lecture was the interaction between serotonin and hormones, particularly estrogen. Estrogen plays an important role in optimizing serotonin signaling by supporting its production, enhancing receptor responsiveness, and modulating serotonin transport mechanisms.

As a result, emotional vulnerability often becomes more noticeable during hormonal transitions such as the premenstrual phase, after childbirth, during perimenopause, or in menopause. These shifts reflect biological recalibration rather than emotional fragility. They represent the brain adapting to changing internal conditions.

Looking Beyond the “Chemical Imbalance” Model

One of the most compelling aspects of the session was its emphasis on a network-based understanding of mental health. Instead of framing psychological conditions as simple neurotransmitter shortages, Dr. Maletic highlighted disruptions in communication across brain circuits.

Serotonin is a vital signaling molecule within this system, but outcomes depend on how effectively multiple networks coordinate. This framework helps explain why responses to stress, medication, or therapy vary widely across individuals and why gender, hormonal context, and neural circuitry all matter in treatment planning.

Key Insights from the Lecture

Serotonin functions primarily as a regulator within interconnected brain systems rather than as a simple mood switch. Differences between men and women reflect variations in synthesis dynamics rather than biological deficits. Hormones, particularly estrogen, strongly influence serotonin signaling, especially during key life-stage transitions.

Mental health conditions arise from circuit-level disruptions rather than isolated chemical imbalances. Individual and gender-specific differences in brain circuitry, hormone levels, and receptor behavior help explain varied responses to antidepressants and therapeutic interventions. A network-oriented understanding of the brain allows for more precise, personalized, and effective mental health care.

Conclusion

The idea that women “have less serotonin” oversimplifies and distorts a far more empowering scientific reality. What research actually reveals is a brain that is highly responsive, hormonally attuned, and dynamically regulated. Sensitivity, in this context, reflects adaptability rather than deficiency.

Dr. Maletic’s lecture reinforces an essential message: mental health is not about identifying shortcomings but about understanding complexity—how brain networks, neurotransmitters, hormones, and lived experience continuously interact to shape emotional well-being.

Reference

Maletic, V.
Brain Networks, Circuits and Neurotransmitters: A Roadmap to Better Outcomes
Presented at the 2023 NEI Congress

 

In this inspiring episode on WahWoman, we speak with Nina af Hällström, spouse of the Consul General of Finland in Mumbai. But Nina is far more than a diplomatic partner — she’s an accomplished political leader, Executive Director in the disability sector, and a proud mother and grandmother. We explore how she’s balanced life across cultures, built a strong career in Finland, and stayed rooted in purpose while living abroad. Tune in to hear her journey of resilience, adaptation, and leadership across borders. Don’t miss this empowering conversation that shines a light on the often-overlooked lives of diplomatic spouses!

 

 

🧠 In association with Ecocivilisation and Terra ZivA, WahWoman proudly hosted a powerful global webinar on mental health:

🎙️ Modern Therapeutic Strategies for Mental Health
This dynamic and insightful conversation brought together international experts who shared cutting-edge therapeutic approaches to support mental well-being.

👥 Speakers:
🔹 Dr. Rajni Vohra
🔹 Eleftheria Kakambouras
🔹 Dr.h.c. Violeta Bulc
🔹 Dr. Ashish M. Gaikwad
🔹 Srinivasa Murthy
🔹 Katarina Habe

🟠 Key Topics Explored:
✅ Cognitive Behavioural Therapy (CBT): Techniques & benefits
✅ Neuroplasticity: How the brain rewires itself for healing
✅ Dialectical Behaviour Therapy (DBT): Applications & effectiveness
✅ Psychodynamic Therapy: Understanding unconscious patterns
✅ Mindfulness-Based Therapy: Practical stress reduction tools

🌍 Mental health deserves global attention and collective wisdom. This webinar was a step toward deepening awareness and sharing transformative strategies that empower individuals and communities alike.

#MentalHealthMatters #GlobalWellbeing #TherapeuticStrategies #Ecocivilisation #WahWoman #TerraZivA #CBT #DBT #Mindfulness #PsychodynamicTherapy #Neuroplasticity #EmpowerYourMin

In association with Ecocivilisation and Terra ZivA, WahWoman proudly hosted a global webinar on mental health:

💬 “Breaking the Silence: Empowering Yourself”
📅 Wednesday, April 23rd, 2025

A heartfelt thank you to our incredible panelists who shared their wisdom, personal journeys, and powerful strategies for building mental resilience and breaking the stigma around mental health.

🟠 PANELISTS:

🔹 Dr. Ruksheda Syeda (India)
A leading psychiatrist with over 24 years of experience, Dr. Syeda specializes in supporting teenagers, young adults, women, and families through her private practice in Mumbai. Currently the President of the Bombay Psychiatric Society, she is also a TEDx speaker and respected media voice on mental wellness.

🔹 Konstantina Cheimara (Greece)
A passionate advocate for mental health and gender-based issues, Konstantina is the founder of the Social Issues Club at The American College of Greece. She’s led initiatives on femicides, trauma, and empowerment and actively supports global platforms like Ecocivilisation to promote social and environmental justice.

🔹 Dawn Evans (United Kingdom)
An inspiring entrepreneur and wellness leader, Dawn is the founder of Wales’ largest Mental Health Event and a certified Mental Health & First Aid tutor. Through her company, Ajuda, she has educated over 150,000 individuals in life-saving mental health and first aid skills. Her passion for coaching and wellness has impacted entrepreneurs and communities worldwide.

🧠💗 Thank you to all who joined us for this deeply empowering conversation. Together, we’re breaking the silence, one voice at a time.

#MentalHealthAwareness #BreakingTheSilence #WahWoman #Ecocivilisation #TerraZivA #GlobalVoices #EmpowerYourself #WellbeingMatters #MentalHealthMatters #WomenSupportingWomen #InternationalVoices #WebinarHighlights

Webinar Recap | Foundation of Mental Health: Why it Matters for Everyone?
🗓️ Wednesday, March 26, 2025
📍 Hosted by WahWoman in association with Ecocivilisation and Terra zivA

Mental health is not a privilege — it’s a fundamental human need.
With this belief at heart, WahWoman held a powerful and insightful webinar titled “Foundation of Mental Health: Why it Matters for Everyone?” bringing together global experts and thought leaders to explore the essential pillars of mental well-being.

💬 Expert Panel Included:

Dr. Om Bedekar – Renowned Psychiatrist with over 35 years of experience, known for his minimal-medication approach to mental health.
Dr. Swati Karve – Esteemed Psychologist, Educator, and CEO of SwastiVishwa Institute, bringing 30+ years of expertise in therapy, education, and organizational training.
Helen Davies – G100 England Regional Chair for Mental Health, a passionate neurodivergent expert and advocate for inclusive mental health practices.

The session emphasized:

  • Preventive and holistic approaches to mental health

  • Addressing neurodivergence and inclusion

  • The need for collective responsibility in destigmatizing mental health

Curated by:
Dr. Rajni Vohra, Eleftheria Kakambouras, and Dr. hc. Violeta Bulc — a dynamic team committed to cross-cultural learning, empathy-driven leadership, and inclusive well-being.

Together, we are building a world where mental health is not hidden, but honored. 
#MentalHealthMatters #WahWoman #Ecocivilisation #TerraZivA #MentalWellbein

wahwoman
International Women’s Day

This International Women’s Day 2025, we are celebrating New Age Women Leadership—bold, visionary, and inspiring!
Are you a Gen Z leader making an impact?
Tell us in less than 100 characters how your leadership is shaping society.
📢 How to participate?
✔ Share your leadership impact (within 100 characters).
✔ Send us your entry along with your picture.
Let’s amplify the voices of young women redefining leadership!

 

Last month, the world observed two significant events: Menopause Awareness Month and World Mental Health Awareness Month. Notably, October 18th marked the 25th anniversary of World Menopause Day.  WahWoman! would like to take the opportunity to spread more awareness about the same.

Sarah, Rachana, and Maria, three strong women who, against the struggle of embarrassment, dared to share their personal experiences.

When I got mixed notifications from my body, that day was really weird for me,” says Sarah, 45. “I thought I was going to go out of control.” Brain fogs, hot flashes, night sweats, and drastic mood swings messed up her once prospering marketing career.

WahWoman

Sarah remembers a meeting in which she seemed to spontaneously combust. “It felt like my hormones were playing a cruel game with her.”

“I barely recognized myself,” Rachana, 42, said. I thought I was going crazy The panic attacks, missed periods, plus forgetfulness along with self-respect were taking a toll on her teaching.

“Sometimes I would mess up and forget my students’ names or I would completely forget I had a lesson plan to do,” Rachana says. “It felt like all the fog had settled down in my brain.”

“I felt like this was going on without my consent,” said Maria, 48. Vaginal dryness, diminished libido, and sleeplessness constrained her very intimacy.

“I felt like I was losing my sense of self,” Maria confides. “It felt like my body was betraying me”

Even though they all come from different backgrounds, one thing that binds them together is ¹PERI MENOPAUSE.

WahWoman

What Is Perimenopause?
We all have heard about perimenopause-it is a confusing and stigmatized transition between the ages of 35-55 probably-2-10 years before menopause, with many millions of cases worldwide.

🔴Hormonal Changes
There are highly varying hormonal levels at the perimenopause:

⭕Estrogen: Drops by 50-70%, thereby resulting in hot flashes, vaginal dryness, and mood swings.

⭕Progesterone: Suppressed, resulting in irregular vaginal bleeding and sleep problems.

⭕Decreased testosterone: With libido and energy mounted.

🔴 Psychological Impact
Along with physical and emotional impact women may experience other psychological issues….As mental well-being profoundly undergoes changes during the perimenopausal period.
⭕ Anxiety and depression
⭕ Loss of identity and self-esteem
⭕ Diminished cognitive function and impaired memory
⭕ Instability of mood and lacking emotional control

🔴Common Symptoms:
Here are most common symptoms out of 70 described so far:

⭕ Sporadic periods
⭕ Flashes of heat
⭕ Nocturnal sweats
⭕ Mood changes
⭕ Sleep disorders
⭕ Frozen shoulder
⭕ Low libido

🔴 Reclaiming Self-Control:
To engage through those crucial years in what follows, we recommend the following changes in lifestyle.:

🔴 Lifestyle Changes:

✅ There should be a healthy look at omega-3s, calcium, and vitamin D.
✅ Regular exercise (yoga, walking, swimming)along with strength training.
✅ Stress management (meditation, deep breathing).
Hygiene.

🔴 Medical Options:

✅ Consult your gynecologist about Hormone Replacement Therapy (HRT) and Non HRT medications.
✅ Consulting alternative therapy like Ayurvedic/Homeopathic medical practitioners can also help out.

🔴The Power of Community

Perimenopause may be a challenging journey, but with support, education, and self-care, you can thrive.

“Sharing my story helped me realize I wasn’t alone,” Sarah says.

“Connecting with others who understand what I’m going through has been lifesaving,” Rachana adds.

Maria nods in agreement. “It’s time to break the silence and empower each other.”

“Menopause: ME (K)no(W)
pause = Me No pause”

is more than just an equation!

It acknowledges the transformative power of menopause, where a woman’s body and mind evolve.
This journey is about self-discovery (“know”) and embracing change, not just a pause in reproductive life.
The equation suggests that life doesn’t stop; it evolves, and women continue to grow.
Let Menopause become a catalyst for renewal, not decline, by embracing this transformation, women can break free and thrive.

Do join the conversation

Share your story. Let’s break this silence!

 

Author,                                                                                                                                                                                                                                 Deepti Joshi,
Founder of Brain Matters and Blossom & Bloom Center, Pune                                                                                                   With Brain Matters, she has helped thousands of parents achieve transformative results for their children by addressing the intricate relationships between diet, environment, thoughts, and emotions.
And with Blossom & Bloom Center I work with Women struggling with getting pregnant and those who are in the Peri menopausal phase.

wahwoman

Social networking isn’t just about growing your circle; it’s about building a supportive community around you. We hope our listeners are inspired to connect more deeply and thoughtfully while watching this podcast. Through this conversation, we explored the nuances of building and nurturing professional relationships in today’s digital age with a remarkable guest, Dr. Dhanashri Hardas, a social networking expert and thought leader in professional development. Dr. Hardas has extensive experience in building connections and creating impact through network and she has shared her insights on ‘The Art of Social Networking”.

About Dr Dhanashri Hardas-

Dr. Dhanashri Hardas is awarded a Ph.D. in Botany for her contributory research in the field of Tribal Medicine. The thesis titled “Ethno medicinal Studies of Plants Used by The Tribal of Thane District”. Dr. Dhanashri Hardas translated the biography of Dharmveer, Dr Balkrushn Shivram Moonje, founder of Bhonsala Military School. She is a Chairperson of Women’s Entrepreneur Wing, Maharashtra Chamber of Commerce, Industry and Agriculture, Dr. Dhanashri Hardas steers the movement inclined towards generation of women entrepreneur power. Besides this, she is President of ‘Women Society for Environment, Culture and Education’, Dr. Dhanashri Hardas devotes the empowerment of women towards trust, beliefs, smart work and global world through Sustainable Environmental program. She is Convener of ‘Blue Revolution – A Paradigm Shift’, an International Conference of Water Sanitation and Recycling Dr. Dhanashri Hardas the best practices of used water all over the globe and now contributing towards local needs..

 

#SocialNetworkingTips #BuildingAuthenticConnections #NetworkingStrategies #ProfessionalRelationships #DigitalNetworking #NetworkingForGrowth #GenuineConnections #EffectiveCommunication #TrustInNetworking #CareerSuccess #RelationshipBuilding #NetworkingForIntroverts #MaintainConnections #DigitalAgeNetworking #NetworkingWithPurpose #EmpathyInNetworking #LongTermRelationships #ActiveListening #NetworkingAdvice #NetworkingForProfessionals

Tanja Miškova is a career diplomat with over 24 years of experience at the Ministry of Foreign Affairs of Slovenia. Her recent work focuses on water diplomacy and the circular economy, two areas of deep passion. Throughout her distinguished career, she has engaged extensively with the Middle East, particularly the Israeli-Arab conflict. She has served as Deputy Head of Mission at the Embassy of Slovenia in Israel and later as Diplomatic Adviser to the President of Slovenia, Dr. Danilo Türk. Upon returning to the ministry, she took on the role of National Coordinator for the Union of the Mediterranean. Additionally, she has served as Ambassador to Egypt, with non-resident accreditation to Jordan, Saudi Arabia, UAE, Kuwait, Qatar, and Oman. Tanja has held key positions such as Head of the Department for Emerging Threats and Challenges, and Acting Director General for Multilateral Affairs, Development Cooperation, and International Law.

                                                    Tanja Miškova

Rajni Vohra: Water is a crucial resource with geopolitical significance. How does Slovenia
approach water diplomacy, especially in regions where water scarcity is a major issue?
Tanja Miškova: Our water diplomacy efforts are focusing on three thematic priorities – 1. Water
peace nexus, 2. Transboundary water cooperation, and 3. Water climate nexus –
and two cross-cutting priorities: gender equality and human rights-based approach.
These efforts are closely aligned with our priorities in human rights agenda, peace
security agenda, and development cooperation and humanitarian assistance.

As a co-founder and the current chair of the Group of Friends on Water and Peace in
Geneva, Slovenia advocates for considering water in conflict prevention, conflict
resolution and peacebuilding efforts, and for protection of water resources and water
infrastructure during and after armed conflicts in accordance with International
Humanitarian Law. We point to the importance of climate resilient post-conflict
recovery and environmental peacebuilding.
These are our messages also during our current two-year tenure as an elected
member of the UN Security Council. We stress on the under-explored potential of
water for preventive action and peacebuilding.

 

Rajni Vohra: Slovenia shares water resources with several neighboring countries. What
strategies and agreements have been most effective in ensuring equitable and
sustainable water management across borders?
Tanja Miškova: We find that transboundary water cooperation is most effective and sustainable  when based on solid institutional and legal framework, grounded in International Water Law and it principles, is based on trust and transparent exchange of data, is sustainably financed, is comprehensive, inclusive, enjoys solid political support but no interference, and brings the sense of equal participation and equal benefits to all riparians. The International Framework Agreement on the Sava River Basin is a prime example of such an agreement.
Transboundary cooperation with neighbours that are not riparians of Sava River
Basin, is based on bilateral frameworks and conducted within bilateral commissions.
Their effectiveness varies; their scope and level of cooperation does not match that
of the Sava River Basin. A wider scope of cooperation widens the range of benefits
each riparian can enjoy as result of cooperation.

 

Rajni Vohra: With climate change intensifying water-related challenges, how does Slovenia
integrate water diplomacy into its broader climate action strategies?
Tanja Miškova: The water climate nexus was not fully recognized in climate negotiations until
recently. This is why Slovenia included the nexus among the priorities of its water
diplomacy. Slovenia was among the most avid proponents of including water into the
UNFCCC COP outcome documents. We contributed to the breakthrough achieved at COP27 in Sharm El Sheikh where the relevance of water-related ecosystems for
climate adaptation was finally recognized in the Outcome Document. We were actively engaged also at COP28 in Dubai. We were partners of the COP28 Water Pavilion and our delegation, including the President, participated in several high-level event related to water and climate.
While the role of water and water-related ecosystems in climate adaptation has now
been recognized, we are still falling short when it comes to recognizing their role in
climate mitigation. Both are relevant not just in terms of calibrating our climate action
accordingly, but also in terms of securing necessary funding for water from climate
finance.

Rajni Vohra: Can you share any examples of successful international collaborations or
initiatives led by Slovenia that have contributed to water security in Europe or globally?
Tanja Miškova: Slovenia initiated the EU Council Conclusions on Water in EU’s  External Action
(2021) which provide political commitment of the EU on global water security in its
humanitarian, development and peace action.
Together with like-minded countries and organizations, we made sure transboundary
water cooperation was on the agenda of the UN 2023 Water Conference, quite an
uphill battle during the preparatory process. Slovenia was one of the first countries to
join the Transboundary Water Cooperation Coalition whose initial aim was to secure
commitments on cross-border cooperation for the Water Action Agenda at the
Conference.
The collaboration Slovenia can be truly proud of is the establishment of the Global
Alliance for Sparing Water from Armed Conflict in partnership with Switzerland and
Geneva Water Hub. The Alliance was launched in May this year together with
Senegal, Costa Rica, Panama, Indonesia, the Philippines, UNICEF and Pax. The
Alliance aims to ensure greater compliance with International Law, better inform on
the impacts of attacks on water, and increase pre-conflict preparedness and
resilience of water infrastructure and essential services through strengthened
collaboration among humanitarian, development and peace actors.

Rajni Vohra: How can water diplomacy be used as a tool to promote gender equality,
particularly in regions where women are disproportionately affected by water scarcity
and management issues?
Tanja Miškova: Slovenia is engaged in two initiatives that subscribe to this particular mission. Multi-stakeholder Coalition for Gender Equality in the Water Domain and its Call to Action, established by UNESCO WWAP, focuses on five key areas:
– promoting gender-equal funding,
– bridging the gap between policy and practice,
– fostering women’s leadership,
– challenging harmful social norms, and
– using sex-disaggregated data to inform water policies.

Slovenia, a member of the coalition, supports its online platform, which serves as a
repository of resources, best practices, and collaborative opportunities related to
gender equality in water.
Global Network of Women in Water Diplomacy authored a guidance on
mainstreaming gender equality in transboundary mechanisms. The network provides
a valuable avenue for exchange of experience, good practices and mentorship
opportunities for women water diplomats from the Nile Basin, South Africa, and
Central Asian  Afghanistan.
In coherence with our Women, Peace and Security agenda, Slovenia advocates for
meaningfully including women in environmental peacebuilding efforts and in water
governance. Our Peace Operations Training Centre conducts a course on Gender
Equality and Gender Mainstreaming in Peace Operations and Missions.
We recently joined the WASH Road Map initiative and its Call to Action, to contribute
to its efforts on access to water and sanitation in humanitarian contexts.
We don’t just talk: we also walk the talk. Our Development Cooperation projects
focus on water-scarce regions. Most of our projects in sub-Saharan Africa have as
their primary aim equitable access to WASH and empowerment of women.

Rajni Vohra: As water becomes an increasingly contested resource, what do you see as the
key priorities for global water diplomacy in the next decade? How is Slovenia
preparing to address these challenges?
Tanja Miškova: Two thirds of watercourses cross national boundaries and one third still lack
cooperative frameworks. This gap is even starker when it comes to transboundary
groundwater bodies and wetlands; only a handful benefit from cooperative
agreements. Therefore, our priority number one is promoting transboundary water
cooperation. We are one of the most active members of the Transboundary Water
Cooperation Coalition and one of the most active parties to the UN Water
Convention. We will be hosting the 10 th Meeting of the Parties of the Convention 23-
25 October in Ljubljana. As a water-rich upstream country that practices effective
transboundary cooperation, and knows from experience water cooperation can be a
conduit to peace, we feel we have special obligation to promote its benefits.
Another priority remains keeping water high on the global agenda as a prerequisite
for accelerated and coordinated action. There are several avenues for that:
– Holding regular high-level intergovernmental UN conferences on water; the
next one will be in December 2026 in the UAE. Unfortunately, it will not have a
negotiated outcome. Our aim is for the following conferences to have one.
Another challenge remains how to bring other sectors to the table. Slovenia
will be engaged in the preparatory process for the 2026 conference to
strengthen the progressive agenda and action on water.
– Ensuring effective global water governance with a strategic and coordinated
approach. This entails an improved, less fragmented governance at the UN
level. The recently adopted UN System-wide Strategy on Water is a good step
in this vein. We look forward to the action plans and will closely follow their
implementation.

We need a strong international voice on water; a UN Special Envoy on Water has finally been appointed. This will add to the coherence of UN efforts, give the voice to those most in need, and help mobilize necessary political will and finance. We will continue to remind our UN interlocutors of the outstanding cross-regional support this initiative enjoys. The worrying trend of weaponization of water needs to be reversed. We will stay intensely engaged towards this goal, including through the activities of the Global Alliance.

Rajni Vohra:  Thank you taking the time to share your valuable insights. Your deep knowledge  and passion for water sustainability truly resonated with us and will undoubtedly inspire many others.

In this insightful episode, we sit down with Krishna Maruthur to explore the essential well-being habits every working woman should adopt to thrive in both their professional and personal lives. From managing stress to achieving a healthy work-life balance, Krishna shares practical tips and strategies that can help women prioritize their mental and physical health, while excelling in their careers. Don’t miss this empowering conversation aimed at fostering resilience, self-care, and holistic well-being. #WellBeing #WomenInWork #MentalHealth #WorkLifeBalance #SelfCare #WomenEmpowerment #CareerSuccess #HealthyHabits #Resilience #KrishnaMaruthur #WomenLeadership #Wellness

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